Cognomen Defrancesco (Defrancesco 
) , across the world, is quite a rare surname. The family name Defrancesco is characteristic of Italy, where it is quite a rare surname, Switzerland, where it is a rare surname, and the United States. Not in comparison with a country's population, it is commonest in the United States, Italy, and Canada. Much less frequently, Defrancesco is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Defrancesco | Canada, Argentina, Italy, United States, Switzerland |
Francesco, and Дефранцесцо
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john defrancesco American jazz musician, US (b. 1940) |
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tony defrancesco American baseball player and coach, US (b. 1963) |
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joey defrancesco American jazz musician, US (b. 1971) |
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| johnny defrancesco American musician, US (b. 1965) |
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| teresa defrancesco researcher |
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| michaela defrancesco researcher |
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| edi defrancesco researcher ORCID ID = 0000-0002-3369-1616 |
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| christopher j defrancesco researcher (ORCID 0000-0002-9974-3263) |
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| alicia s defrancesco researcher |
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