Cognomen Santangelo (Santangelo 
, Сантанжело 
, Сантанджело ) , around the globe, is a common surname. The cognomen Santangelo is habitual in Italy, where it is quite a common surname, Argentina, where it is quite a rare surname, and Malta. Measured by absolute frequency, it most frequently occurs in Italy, the United States, and Argentina. Much less frequently, Santangelo is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Santangelo | France, Argentina, Italy, Brazil, United States |
| Сантанджело, Сантанжело | Ukraine |
Santàngelo, Santángelo, Santângelo, and Сантангело
| antonio di santangelo Italian jurist (14. century) (b. 1400) |
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nicola santangelo Italian politician (1754-1851), IT (b. 1754) |
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| gaetano santangelo Italian puppeteer, IT (b. 1782) |
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| nicola santangelo IT (b. 1785) |
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| michele santangelo Italian numismatist (b. 1796) |
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alfred e. santangelo American politician, US (b. 1912) |
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| salvatore santangelo IT (b. 1878) |
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| giovan battista santangelo Italian engineer and teacher, IT (b. 1899) |
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| r. santangelo author (20th century) (b. 1901) |
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| maria santangelo Italian archaeologist (1913-1998), IT (b. 1913) |
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| giorgio santangelo born:1917-01-28|died:1999-05-11|; Santangelo, Giorgio 1917-1999; Santangelo, Giorgio, 1917-1997; Santangelo, Giorgio 1917-, IT (b. 1917) |
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f. p. santangelo American baseball player, US (b. 1967) |
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vincenzo santangelo Italian politician, IT (b. 1972) |
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matt santangelo American basketball player, US (b. 1977) |
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george santangelo American genomicist and data scientist, US |
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