Cognomen Santis (Santis 
, Сантіс 
, Сантис 
) , around the globe, is a common last name. The surname Santis is habitual in Cyprus, where it is quite a common surname, Chile, and Guatemala, where it is quite a rare surname. Not in comparison with a country's population, it is the most numerous in Mexico, Italy, and Chile. Very seldom, Santis is the forename as well as the last name.
| orazio di santis Italian painter (1530-1584), IT (b. 1530) |
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| marc'antonio de santis (b. 1550) |
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joe de santis actor (1909-1989), US (b. 1909) |
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reinaldo de santis FR (b. 1928) |
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luisa de santis Italian actress and singer, IT (b. 1944) |
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omar saavedra santis Chilean author, CL (b. 1944) |
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daniel de santis Argentine politician, AR (b. 1948) |
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orchidea de santis Italian actress, IT (b. 1948) |
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| orlando santis Chilean association football player, CL (b. 1901) |
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salvador llorac i santis ES (b. 1944) |
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| mario de santis Roman Catholic bishop (1904-1985) (b. 1904) |
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| bruno de santis Italian association football player, IT (b. 1909) |
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| luigi de santis Roman Catholic clergyman (b. 1911) |
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| vincent p. de santis American historian, US (b. 1917) |
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| amleto de santis IT (b. 1908) |
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